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Table 1 Overall mosaicism findings in the cingulate cortex (CC) and SN

From: Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing

  Numbers of cells analysed for SNCA gains Cells with SNCA gains
Overall Per case (%)
Disease Region Cell type Total Per case (mean, SD) Number % Median Mean (SD)
MSA CC Neuron 1359 97.1 (21.8) 38 2.80 2.27 2.94 (1.90)
Non-neuron 1513 108.1 (15.3) 23 1.50 1.67 1.60 (0.95)
SN NM+ 1282 85.5 (9.7) 41 3.20 2.67 3.26 (1.88)
NM- 3397 226.5 (32.8) 103 3.04 2.49 3.01 (1.77)
PD CC Neuron 2533 97.4 (10.2) 58 2.29 2.1 2.31 (1.68)
Non-neuron 2851 109.7 (16.5) 33 1.16 0.97 1.23 (0.77)
Other LB CC Neuron 249 83 (9.5) 7 2.81 2.60 2.78 (0.35)
Non-neuron 296 98.7 (26.8) 2 0.68 0.78 0.63 (0.57)
SN NM+ 411 82.2 (6.8) 13 3.16 3.57 3.13 (1.23)
NM- 897 179.4 (27.7) 21 2.34 2.63 2.43 (0.96)
Control CC Neuron 1702 100.1 (19.7) 19 1.12 0.95 1.20 (1.08)
Non-neuron 2028 119.3 (24.6) 16 0.79 0.92 0.76 (0.57)
  1. The cell numbers analysed in each case are provided as a total, with the mean and SD per case. The numbers per individual case are shown in Additional file 2: Figure S2. The % mosaicism for SNCA gains of each disease / region / cell type is provided overall, as well as the median, mean and SD per case. “Other LB” refers to ILBD, except for one SN which was from a case of DLB