Fig. 4

Examples of single cell WGS profiles showing CNVs. The WGS profile is shown for each, with a picture of the nucleus on the right. Scale bar 20 μm. Gains are losses are marked by dots at the respective copy numbers. The cell number is in brackets. a Pontine neuron with gains including SNCA (blue arrow), and adjacent to GBA (red arrow) (K3). b Pontine neuron with a nuclear inclusion and a gain over GRID2 (arrowed) (X21). c Nigral neuron with a cytosolic inclusion and two gains (H11). The dots representing losses are CNVs that were filtered based on the copy number criterion, and therefore have not been included in the analysis. d Putaminal neuron with a nuclear inclusion and multiple losses, including the SNCA region (L33). See also Additional file 2: Figure S6d. e Pontine non-neuronal cell with a cytoplasmic inclusion and likely tetraploidy with superimposed losses (D8)