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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing

Fig. 3

Single cell WGS profiles of cells with known germline SNCA CNVs (arrow). a Fibroblast with triplication. Note additional calls (gain in chr2, telomeric losses in chr4 and 8). b Lower quality fibroblast with triplication, which narrowly fails confidence score filter, and would thus not be analysed. Note increased “waviness”, and likely false positive losses in regions of a negative wave, or near centromeres. c Cortical neuron with duplication. Note the clear differentiation of the XY chromosome copy number in this male

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