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Table 7 Association between symptom onset and AT8 tau pathology

From: Tau pathology in the medial temporal lobe of athletes with chronic traumatic encephalopathy: a chronic effects of neurotrauma consortium study

  Neurons with NFT Neurons with punctate p-tau Total neuronsa Neurite clusters Dystrophic neurites Total pathologyb
Age at symptom onset
 PrCc 0.59d *** 0.46 ** 0.58 *** 0.65 *** 0.46 ** 0.53 ***
 EC 0.62 *** 0.57 *** 0.57 *** 0.50 ** 0.29 0.47 **
 DG 0.63 *** 0.41 * 0.58 *** 0.41 * 0.61 *** 0.60 ***
 CA3 0.47 ** 0.16 0.43 * 0.42 * 0.51 ** 0.48 **
 CA1 0.50 ** 0.23 0.43 ** 0.58 *** 0.50 ** 0.59 ***
 Sub 0.52 *** 0.26 0.48 ** 0.41 * 0.41 * 0.51 **
 PrS 0.61 *** 0.52 *** 0.65 *** 0.49 ** 0.50 ** 0.57 ***
Years from retirement to symptom onset
 PrC 0.50 ** 0.36 0.49 ** 0.57 *** 0.38 * 0.45 **
 EC 0.52 ** 0.53 ** 0.48 ** 0.44 ** 0.22 0.40 *
 DG 0.50 ** 0.41 0.49 ** 0.39 0.51 ** 0.50 **
 CA3 0.40 * 0.09 0.33 0.34 0.40 * 0.37
 CA1 0.41 * 0.17 0.33 0.54 *** 0.45 ** 0.53 ***
 Sub 0.52 ** 0.24 0.48 ** 0.44 ** 0.42 * 0.52 ***
 PrS 0.56 *** 0.49 ** 0.58 *** 0.45 ** 0.50 ** 0.55 ***
  1. aNeurons with NFT and punctate p-tau neurons
  2. bNeurons with NFT, punctate p-tau neurons, neurite clusters, dystrophic neurites
  3. cPrC Perirhinal cortex, EC Entorhinal cortex, DG Dentate gyrus, CA3 Hippocampus CA3, CA1 Hippocampus CA1, Sub Subiculum, PrS Pre−/parasubiculum
  4. dSpearman rank order correlation with Benjamini-Hochberg false discovery critical values, * p < 0.05, ** p < 0.01, *** p < 0.001