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Table 7 Association between symptom onset and AT8 tau pathology

From: Tau pathology in the medial temporal lobe of athletes with chronic traumatic encephalopathy: a chronic effects of neurotrauma consortium study

 Neurons with NFTNeurons with punctate p-tauTotal neuronsaNeurite clustersDystrophic neuritesTotal pathologyb
Age at symptom onset
 PrCc0.59d ***0.46 **0.58 ***0.65 ***0.46 **0.53 ***
 EC0.62 ***0.57 ***0.57 ***0.50 **0.290.47 **
 DG0.63 ***0.41 *0.58 ***0.41 *0.61 ***0.60 ***
 CA30.47 **0.160.43 *0.42 *0.51 **0.48 **
 CA10.50 **0.230.43 **0.58 ***0.50 **0.59 ***
 Sub0.52 ***0.260.48 **0.41 *0.41 *0.51 **
 PrS0.61 ***0.52 ***0.65 ***0.49 **0.50 **0.57 ***
Years from retirement to symptom onset
 PrC0.50 **0.360.49 **0.57 ***0.38 *0.45 **
 EC0.52 **0.53 **0.48 **0.44 **0.220.40 *
 DG0.50 **0.410.49 **0.390.51 **0.50 **
 CA30.40 *0.090.330.340.40 *0.37
 CA10.41 *0.170.330.54 ***0.45 **0.53 ***
 Sub0.52 **0.240.48 **0.44 **0.42 *0.52 ***
 PrS0.56 ***0.49 **0.58 ***0.45 **0.50 **0.55 ***
  1. aNeurons with NFT and punctate p-tau neurons
  2. bNeurons with NFT, punctate p-tau neurons, neurite clusters, dystrophic neurites
  3. cPrC Perirhinal cortex, EC Entorhinal cortex, DG Dentate gyrus, CA3 Hippocampus CA3, CA1 Hippocampus CA1, Sub Subiculum, PrS Pre−/parasubiculum
  4. dSpearman rank order correlation with Benjamini-Hochberg false discovery critical values, * p < 0.05, ** p < 0.01, *** p < 0.001