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Table 7 Association between symptom onset and AT8 tau pathology

From: Tau pathology in the medial temporal lobe of athletes with chronic traumatic encephalopathy: a chronic effects of neurotrauma consortium study

 

Neurons with NFT

Neurons with punctate p-tau

Total neuronsa

Neurite clusters

Dystrophic neurites

Total pathologyb

Age at symptom onset

 PrCc

0.59d ***

0.46 **

0.58 ***

0.65 ***

0.46 **

0.53 ***

 EC

0.62 ***

0.57 ***

0.57 ***

0.50 **

0.29

0.47 **

 DG

0.63 ***

0.41 *

0.58 ***

0.41 *

0.61 ***

0.60 ***

 CA3

0.47 **

0.16

0.43 *

0.42 *

0.51 **

0.48 **

 CA1

0.50 **

0.23

0.43 **

0.58 ***

0.50 **

0.59 ***

 Sub

0.52 ***

0.26

0.48 **

0.41 *

0.41 *

0.51 **

 PrS

0.61 ***

0.52 ***

0.65 ***

0.49 **

0.50 **

0.57 ***

Years from retirement to symptom onset

 PrC

0.50 **

0.36

0.49 **

0.57 ***

0.38 *

0.45 **

 EC

0.52 **

0.53 **

0.48 **

0.44 **

0.22

0.40 *

 DG

0.50 **

0.41

0.49 **

0.39

0.51 **

0.50 **

 CA3

0.40 *

0.09

0.33

0.34

0.40 *

0.37

 CA1

0.41 *

0.17

0.33

0.54 ***

0.45 **

0.53 ***

 Sub

0.52 **

0.24

0.48 **

0.44 **

0.42 *

0.52 ***

 PrS

0.56 ***

0.49 **

0.58 ***

0.45 **

0.50 **

0.55 ***

  1. aNeurons with NFT and punctate p-tau neurons
  2. bNeurons with NFT, punctate p-tau neurons, neurite clusters, dystrophic neurites
  3. cPrC Perirhinal cortex, EC Entorhinal cortex, DG Dentate gyrus, CA3 Hippocampus CA3, CA1 Hippocampus CA1, Sub Subiculum, PrS Pre−/parasubiculum
  4. dSpearman rank order correlation with Benjamini-Hochberg false discovery critical values, * p < 0.05, ** p < 0.01, *** p < 0.001