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Table 6 Regional age-adjusted regression estimates of CTE tau pathology

From: Tau pathology in the medial temporal lobe of athletes with chronic traumatic encephalopathy: a chronic effects of neurotrauma consortium study

  Neurons with NFT Neurons with punctate p-tau Neurite clusters Dystrophic neurites
PrCa 0.95 (0.46, 1.44)b *** 0.89 (0.37, 1.41) *** 1.59 (0.94, 2.23) *** 0.88 (0.44, 1.31) ***
EC 0.99 (0.44, 1.54) ** 0.41 (−0.15, 0.95) 1.50 (0.75, 2.23) *** 0.95 (0.93, 0.98) ***
DG 0.77 (−0.10, 1.58) 1.10 (0.13, 2.05) * 0.61 (0.50, 0.71) *** 0.63 (−0.09, 1.34)
CA3 0.50 (−0.07, 1.06) 0.19 (−0.62, 0.98) 0.76 (− 0.20, 1.66) 0.44 (− 0.12, 0.99)
CA1 0.67 (0.12, 1.20) * 0.26 (−0.34, 0.85) 1.22 (0.55, 1.86) *** 0.55 (0.05, 1.03) *
Sub 0.69 (0.14, 1.22) * 0.32 (0.27, 0.38) *** 1.29 (0.36, 2.17) * 1.06 (0.34, 1.76) **
PrS 1.10 (0.55, 1.64) *** 0.80 (0.16, 1.43) * 1.12 (0.21, 2.01) * 0.79 (0.26, 1.30) *
  1. aPrC Perirhinal cortex, EC Entorhinal cortex, DG Dentate gyrus, CA3 Hippocampus CA3, CA1 Hippocampus CA1, Sub Subiculum, PrS Pre−/parasubiculum
  2. bage-at-death associated regression coefficient (95% confidence interval) with false discovery rate α = 0.03, * p < 0.05, ** p < 0.01, *** p < 0.001