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Table 5 Association between athlete age and AT8 p-tau pathology

From: Tau pathology in the medial temporal lobe of athletes with chronic traumatic encephalopathy: a chronic effects of neurotrauma consortium study

 

Neurons with NFT

Neurons with punctate p-tau

Total neuronsa

Neurite clusters

Dystrophic neurites

Total pathologyb

Age at death

 PrCc

0.64d ***

0.55 ***

0.65 ***

0.66 ***

0.55 ***

0.63 ***

 EC

0.65 ***

0.49 **

0.61 ***

0.63 ***

0.49 **

0.60 ***

 DG

0.60 ***

0.63 ***

0.67 ***

0.51 **

0.63 ***

0.66 ***

 CA3

0.57 ***

0.18

0.48 **

0.59 ***

0.50 **

0.53 ***

 CA1

0.58 ***

0.22

0.48 **

0.65 ***

0.53 ***

0.61 ***

 Sub

0.61 ***

0.27

0.56 ***

0.49 **

0.46 **

0.57 ***

 PrS

0.58 ***

0.57 ***

0.62 ***

0.49 **

0.53 ***

0.59 ***

Years from retirement to death

 PrC

0.52 ***

0.40 *

0.52 ***

0.52 ***

0.41 **

0.49 **

 EC

0.53 ***

0.49 **

0.50 **

0.54 ***

0.38 *

0.50 **

 DG

0.42 *

0.62 ***

0.54 **

0.45 **

0.54 **

0.56 ***

 CA3

0.48 **

0.15

0.38 *

0.45 **

0.37

0.40 *

 CA1

0.46 **

0.19

0.38 *

0.58 ***

0.46 **

0.53 ***

 Sub

0.60 ***

0.30

0.56 ***

0.52 ***

0.45 **

0.56 ***

 PrS

0.52 ***

0.47 **

0.54 ***

0.43 **

0.54 ***

0.57 ***

  1. aNeurons with NFT and punctate p-tau neurons
  2. bNeurons with NFT, punctate p-tau neurons, neurite clusters, dystrophic neurites
  3. cPrC Perirhinal cortex, EC Entorhinal cortex, DG Dentate gyrus, CA3 Hippocampus CA3, CA1 Hippocampus CA1, Sub Subiculum, PrS Pre−/parasubiculum
  4. dSpearman rank order correlation with Benjamini-Hochberg false discovery critical values, * p < 0.05, ** p < 0.01, *** p < 0.001