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Table 5 Association between athlete age and AT8 p-tau pathology

From: Tau pathology in the medial temporal lobe of athletes with chronic traumatic encephalopathy: a chronic effects of neurotrauma consortium study

  Neurons with NFT Neurons with punctate p-tau Total neuronsa Neurite clusters Dystrophic neurites Total pathologyb
Age at death
 PrCc 0.64d *** 0.55 *** 0.65 *** 0.66 *** 0.55 *** 0.63 ***
 EC 0.65 *** 0.49 ** 0.61 *** 0.63 *** 0.49 ** 0.60 ***
 DG 0.60 *** 0.63 *** 0.67 *** 0.51 ** 0.63 *** 0.66 ***
 CA3 0.57 *** 0.18 0.48 ** 0.59 *** 0.50 ** 0.53 ***
 CA1 0.58 *** 0.22 0.48 ** 0.65 *** 0.53 *** 0.61 ***
 Sub 0.61 *** 0.27 0.56 *** 0.49 ** 0.46 ** 0.57 ***
 PrS 0.58 *** 0.57 *** 0.62 *** 0.49 ** 0.53 *** 0.59 ***
Years from retirement to death
 PrC 0.52 *** 0.40 * 0.52 *** 0.52 *** 0.41 ** 0.49 **
 EC 0.53 *** 0.49 ** 0.50 ** 0.54 *** 0.38 * 0.50 **
 DG 0.42 * 0.62 *** 0.54 ** 0.45 ** 0.54 ** 0.56 ***
 CA3 0.48 ** 0.15 0.38 * 0.45 ** 0.37 0.40 *
 CA1 0.46 ** 0.19 0.38 * 0.58 *** 0.46 ** 0.53 ***
 Sub 0.60 *** 0.30 0.56 *** 0.52 *** 0.45 ** 0.56 ***
 PrS 0.52 *** 0.47 ** 0.54 *** 0.43 ** 0.54 *** 0.57 ***
  1. aNeurons with NFT and punctate p-tau neurons
  2. bNeurons with NFT, punctate p-tau neurons, neurite clusters, dystrophic neurites
  3. cPrC Perirhinal cortex, EC Entorhinal cortex, DG Dentate gyrus, CA3 Hippocampus CA3, CA1 Hippocampus CA1, Sub Subiculum, PrS Pre−/parasubiculum
  4. dSpearman rank order correlation with Benjamini-Hochberg false discovery critical values, * p < 0.05, ** p < 0.01, *** p < 0.001