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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Tau pathology in the medial temporal lobe of athletes with chronic traumatic encephalopathy: a chronic effects of neurotrauma consortium study

Fig. 2

Photomicrograph, topographical maps and scatterplot of AT8 immunolabeling in the medial temporal lobe (MTL). a Low magnification image showing areas of the MTL evaluated for AT8 immunoreactivity. Abbreviations: PrC, perirhinal cortex; EC, entorhinal cortex; DG, dentate gyrus; CA3 and CA1, hippocampal subfields; Sub, subiculum; PrS, pre−/parasubiculum (arrow indicates rhinal sulcus). Note the lamina distribution of AT8-positive labeling in CA1, EC layers V-VI and II, and PrC. Scale bar = 5 mm. b and d Representative topographic maps show distribution of AT8 immunopositive tangle-bearing neurons (blue solid circle), neurons displaying puncta (pink open circle), neurite clusters (green triangle), glia and small local interneurons (gray dots) in CTE stage III (b) and stage IV (d). Note the increase in the extent and density of the various tau pathologies in stage IV compared to stage III. c Staggered scatterplot demonstrates pathology overlap across CTE stages. While there is large overlap, pathology clusters at the low end in stage II (green) and at the high end in stage IV (blue). Each data point represents a subject:region pairing

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