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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

Fig. 1

Different α-syn strains induce pser129 inclusions in the olfactory bulb with different seeding efficiencies. a α-Syn inclusions in the injected olfactory bulb (OB) at 3- and 6-months post injection (MPI), detected by an antibody anti-α-syn phosphorylated on serine 129 (pser129). b α-Syn inclusions measured by densitometry of the pser129 staining in ipsilateral and contralateral OB, 3- and 6-MPI. Immunostaining for pser129 was performed in eight independent histochemical experiments. Densitometry performed on 3–5 animals per group (3 MPI: monomers, n = 4; Fibrils, n = 5; Ribbons, n = 5; F-65, n = 5; F-91, n = 5; F-110, n = 5; 6 MPI: monomers, n = 3; Fibrils, n = 5; Ribbons, n = 5; F-65, n = 4; F-91, n = 5; F-110, n = 5). Statistical analyses were performed by linear mixed-effect model and included 3 factors (strains, ipsilateral / contralateral sides, and delay post injection). Data are presented after log2-transformation. Boxes represent the 25th to 75th percentiles. The median and the mean are represented in each box by the line and the cross respectively. Error bars correspond to the minimal and maximal values measured. * comparison monomers to strains within same group of age and side; # comparison between strains within same group of age and side; + comparison between 3 and 6 months, same injectate, same side. No significant interaction between time and side. Statistics are available in Additional file 5. Scale bar: 25 μm

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