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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice

Fig. 6

MB decreases activated astrocytes in the hippocampal fiber systems and the white matter of ACL/G Casp6 mice. Representative micrographs, bar = 50 μm (a, c, e, g) and quantitation (b, d, f, h) of GFAP-immunopositive astrocytes (μm2 immunopositive GFAP/100μm2 area) in hippocampus CA1 (a&b), corpus callosum (c&d), fimbria (e&f), and fornix (g&h) of vehicle-treated ACL/G (KI/Cre n = 5, KI/WT n = 3), WT/Cre (n = 3), WT/WT (n = 3) or MB-treated ACL/G (KI/Cre n = 2, KI/WT n = 1),WT/Cre (n = 3), and WT/WT (n = 3) mice. Data represents mean and s.e.m. Statistical evaluations were conducted with Brown-Forsythe ANOVA p < 0.001 (d, f, h) Post-hoc analyses were done with Dunnett’s test. ***p < 0.001, ****p < 0.0001 vs vehicle-treated WT/WT. # # #p < 0.001, # # # #p < 0.0001 vs vehicle-treated ACL/G

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