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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis

Fig. 8

Immunoglobulin signatures and B cells in WM lesions of patients with progressive MS. a. Immunoglobulin transcripts among the top 10 upregulated DEGs in the global MS WM tissue compared to control WM tissue. b. Heatmap of immunoglobulin transcripts in the different lesion types and NAWM. c. Number of CD20+ cells in active (n = 3) and remyelinating (n = 4) lesions, each lesion from different brains. The same brains and lesions were used for generating transcriptome signatures. Around 10 pictures per lesion in each patient were taken at magnification of 20x and the average cell number per lesion were calculated. Statistical difference between the CD20+ cells was calculated using the Mann-Whitney test. Immunohistochemistry shows CD20+ cells at small vessels within an active and remyelinating MS lesion, respectively. FDR: false discovery rate; DEGs: differentially expressed genes (FDR < 0.05); WM: white matter; NAWM: normal appearing WM

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