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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis

Fig. 3

TGFβ-R2 as a major hub in the common MS lesion-specific de novo network. a. De-novo enriched protein-protein network of the 282 DEGs that were expressed in all MS WM tissue 84 nodes, 169 protein connections). b. Genes of TGFβ receptors and ligands in different lesion types. Asterisks indicate significant changes (*FDR < 0.05, **FDR < 0.01, ***FDR < 0.001). The number indicate the fold change (FC). c. TGFβ-R2 protein expression in remyelinating lesions by immunohistochemistry. d. TGFBR2 (green) RNA co-localizes with GFAP (red) RNA in remyelinating lesions by RNAscope. e. TGFBR2 (green) RNA do not co-localize with IBA1 RNA by RNAscope in remyelinating lesions. FDR: false discovery rate; DEGs: differentially expressed genes (FDR < 0.05)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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