Fig. 6

Escalating supersaturation of an aggregation-prone subproteome puts affected fibers at risk of inclusion formation in inclusion body myositis. 1) Supersaturation of the aggregate proteome increases to the point of aggregate formation at muscle inclusion bodies (gray regions). 2) The most highly supersaturated proteins decrease in abundance upon approaching the inclusion body. In contrast, the abundance of the aggregate/RV enriched supersaturated proteome increases and escapes downregulation