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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: A metastable subproteome underlies inclusion formation in muscle proteinopathies

Fig. 4

Escalating supersaturation in inclusion body myositis. Comparison of folded supersaturation scores (σf) for the proteome (Prt) and proteins enriched in rimmed vacuoles (RV) relative to diseased control myofibers. a Healthy control myofiber (HC) (Prt N = 1605, RV N = 47), b control myofibers unaffected in diseased samples (DC) (Prt N = 1988, RV N = 52), c aggregate-containing affected myofibers (AF) (Prt N = 2396, RV N = 52), and (d) rimmed vacuoles (RV) (Prt N = 2104, RV N = 52). e Comparison of the fold difference in median σf between RV and Prt. Box plots and statistical tests as in Fig. 1. *p < 0.05, ***p < 0.001, ****p < 0.0001

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