Fig. 4From: A metastable subproteome underlies inclusion formation in muscle proteinopathiesEscalating supersaturation in inclusion body myositis. Comparison of folded supersaturation scores (σf) for the proteome (Prt) and proteins enriched in rimmed vacuoles (RV) relative to diseased control myofibers. a Healthy control myofiber (HC) (Prt N = 1605, RV N = 47), b control myofibers unaffected in diseased samples (DC) (Prt N = 1988, RV N = 52), c aggregate-containing affected myofibers (AF) (Prt N = 2396, RV N = 52), and (d) rimmed vacuoles (RV) (Prt N = 2104, RV N = 52). e Comparison of the fold difference in median σf between RV and Prt. Box plots and statistical tests as in Fig. 1. *p < 0.05, ***p < 0.001, ****p < 0.0001Back to article page