Fig. 1
From: A metastable subproteome underlies inclusion formation in muscle proteinopathies
A protein aggregates when its concentration exceeds its solublity, thus becoming supersaturated. Supersaturated proteins tend to be abundantly expressed despite having a relatively low solubility. Disruptions in the protein homostasis system favor protein aggregate formation whereas an enhancement in protein homeostasis favors protein solubility (dashed lines). The translational repression of abundant aggregation-prone proteins favors a non-aggregated proteomic state. Protein inclusions in diseased tissue are heterogenous and composed of multiple proteins that have exceeded their solubility threshold