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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients

Fig. 2

qPCR analysis for KCC2 and NKCC1 in RTT brain samples. KCC2 expression levels are reduced in all 3 RTT patient brains compared to control 3 control brains (a). Reduced KCC2 expression levels are found in all brain regions studied, but only reached statistical significance in BA6 (Multiple t test BA6 p < 0.01; one-way ANOVA P < 0,0001) (b). NKCC1 expression levels are unchanged in RTT patient brains (c). The KCC2/NKCC1 ratio is significantly reduced in RTT patient brains (Mann-Whitney test P < 0,007) (d). Averaged expression levels of KCC2 isotypes are reduced in RTT samples, which reached statistical significance for KCC2a (2-Way-ANOVA P < 0,005) but not for KCC2b expression (2-Way-ANOVA, ns) (e)

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