Fig. 2

Heterogeneity in accessibility of transcription factors within gliomas with IDH mutation. a t-SNE plot of snATAC-seq data, b Accessibility heatmap of the markers that separate the two blue and red states, as shown in (a), category 1 indicates the blue cluster, and category 2 indicates the red cluster, c Normalized ATAC-seq coverage for the single nuclei from IDHmut-codel and IDHmut-noncodel samples for chromosome 1 (left) and chromosome 19 (right). The 1p/19q co-deletion in a subset of cells is seen when comparing the IDHmut-codel to IDHmut-noncodel nuclei, d t-SNE plot of the transcription factor variability scores obtained from chromVAR, e Ranked plot of variability scores for 386 TF motifs (chromVAR), f t-SNE plot of variability scores for FOSL1 (chromVAR), g t-SNE plot of variability scores for NHLH1 (chromVAR)