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Table 1 Clinicopathological information of included patients for immunohistochemistry and primary microglia isolation

From: Regulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment

Patient

Age

Gender

Diagnosis

Disease duration * (years)

Post-mortem delay (h)

Cause of death

Lesions

Immunohistochemistry

1

60

M

SPMS

16

8:49

Euthanasia

1 aWML, NAWM, NAGM

2

48

M

PPMS

18

6:35

Dehydration

2 aWML, 2 cWML, 2 sGML, NAWM, NAGM

3

66

F

PPMS

27

9:45

Pneumonia

1 sGML, NAWM, NAGM

4

52

F

PPMS

25

8:40

Euthanasia

1 cWML, 1 sGML, NAWM, NAGM,

5

74

F

PPMS

16

10:30

Respiratory failure

1 sGML, NAWM, NAGM,

6

65

F

SPMS

22

10:45

Brain infarction

2 cWML, 1 sGML, NAWM, NAGM,

7

66

F

SPMS

22

6:00

Unknown

2 aWML, 1 sGML, NAWM, NAGM

8

51

M

SPMS

20

11:00

Unknown

2 aWML, 1 cWML, NAGM

9

50

F

SPMS

12

9:05

Euthanasia

1 aWML, 1 sGML, NAWM,

10

50

M

SPMS

21

10:50

Euthanasia

1 aWML, NAWM, NAGM

11

54

M

PPMS

12

8:15

Euthanasia

1 cWML,1 sGML

12

54

F

SPMS

23

9:25

Respiratory failure

1 aWML

13

47

F

SPMS

27

8:35

Pneumonia

1 aGML

14

53

M

PPMS

2

5:30

Pneumonia

1 leukocortical lesion

15

41

F

SPMS

11

8:25

Natural causes

1 leukocortical lesion

16

45

M

SPMS

20

7:45

Cardiac Arrest

1 leukocortical lesion

17

54

F

SPMS

24

9:10

Dyspnea followed by palliative care

1 leukocortical lesion

18

57

F

SPMS

25

10:40

Euthanasia

1 leukocortical lesion

Primary microglia isolation

15

81

M

PD

38

8:05

Septic Shock

 

16

65

M

SPMS

34

9:30

Euthanasia

17

51

F

SPMS

17

9:10

Euthanasia

18

70

M

SPMS

33

9:25

Euthanasia

19

81

F

PD

7

10:50

Respiratory Failure

20

76

F

Hypokinesia / PD

9

9:15

Heart Failure

21

67

F

PPMS

16

5:45

Euthanasia

22

35

F

Neuropathic pain

8

5:20

Euthanasia

23

65

F

MSA-P

3

7:05

Euthanasia

24

67

M

PPMS

11

7:55

Euthanasia

25

52

F

PPMS

2

9:30

Euthanasia

26

83

F

PPMS

34

7:40

Ovarian Cancer

  1. M male, F female, SP Secondary progressive, PP Primary progressive, PD Parkinson’s Disease, MSA-P Multiple System Atrophy-Parkinsonism, * Starting from first diagnosis, NAGM normal appearing grey matter, NAWM normal appearing white matter, cWML chronic white matter lesion, aWML active white matter lesion, sGML subpial grey matter lesion, aGML active grey matter lesion