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Table 1 Clinicopathological information of included patients for immunohistochemistry and primary microglia isolation

From: Regulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment

Patient Age Gender Diagnosis Disease duration * (years) Post-mortem delay (h) Cause of death Lesions
Immunohistochemistry
1 60 M SPMS 16 8:49 Euthanasia 1 aWML, NAWM, NAGM
2 48 M PPMS 18 6:35 Dehydration 2 aWML, 2 cWML, 2 sGML, NAWM, NAGM
3 66 F PPMS 27 9:45 Pneumonia 1 sGML, NAWM, NAGM
4 52 F PPMS 25 8:40 Euthanasia 1 cWML, 1 sGML, NAWM, NAGM,
5 74 F PPMS 16 10:30 Respiratory failure 1 sGML, NAWM, NAGM,
6 65 F SPMS 22 10:45 Brain infarction 2 cWML, 1 sGML, NAWM, NAGM,
7 66 F SPMS 22 6:00 Unknown 2 aWML, 1 sGML, NAWM, NAGM
8 51 M SPMS 20 11:00 Unknown 2 aWML, 1 cWML, NAGM
9 50 F SPMS 12 9:05 Euthanasia 1 aWML, 1 sGML, NAWM,
10 50 M SPMS 21 10:50 Euthanasia 1 aWML, NAWM, NAGM
11 54 M PPMS 12 8:15 Euthanasia 1 cWML,1 sGML
12 54 F SPMS 23 9:25 Respiratory failure 1 aWML
13 47 F SPMS 27 8:35 Pneumonia 1 aGML
14 53 M PPMS 2 5:30 Pneumonia 1 leukocortical lesion
15 41 F SPMS 11 8:25 Natural causes 1 leukocortical lesion
16 45 M SPMS 20 7:45 Cardiac Arrest 1 leukocortical lesion
17 54 F SPMS 24 9:10 Dyspnea followed by palliative care 1 leukocortical lesion
18 57 F SPMS 25 10:40 Euthanasia 1 leukocortical lesion
Primary microglia isolation
15 81 M PD 38 8:05 Septic Shock  
16 65 M SPMS 34 9:30 Euthanasia
17 51 F SPMS 17 9:10 Euthanasia
18 70 M SPMS 33 9:25 Euthanasia
19 81 F PD 7 10:50 Respiratory Failure
20 76 F Hypokinesia / PD 9 9:15 Heart Failure
21 67 F PPMS 16 5:45 Euthanasia
22 35 F Neuropathic pain 8 5:20 Euthanasia
23 65 F MSA-P 3 7:05 Euthanasia
24 67 M PPMS 11 7:55 Euthanasia
25 52 F PPMS 2 9:30 Euthanasia
26 83 F PPMS 34 7:40 Ovarian Cancer
  1. M male, F female, SP Secondary progressive, PP Primary progressive, PD Parkinson’s Disease, MSA-P Multiple System Atrophy-Parkinsonism, * Starting from first diagnosis, NAGM normal appearing grey matter, NAWM normal appearing white matter, cWML chronic white matter lesion, aWML active white matter lesion, sGML subpial grey matter lesion, aGML active grey matter lesion