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Table 1 Individual case information. Cases were recoded according to their PHF1% load in hippocampus into their respective NFT score (“-“≤ 0.01%; 0.01%< “+” ≤1%;”++” > 1%). Hipp = Hippocampus. BG = Basal Ganglia. TCx = Temporal Cortex. ADRC = Alzheimer’s disease related changes

From: Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer’s disease and not in other tauopathies

ID Diagnosis ABC score Sex Age NFT score Region
High NFT 1 AD A3,B3,C3 M 89 ++ Hipp
High NFT 2 AD A3,B3,C3 F 80 ++ Hipp + BG
High NFT 3 AD A3,B3,C3 F 86 ++ Hipp
High NFT 4 AD A3,B3,C3 F 98 ++ Hipp
High NFT 5 AD A3,B3,C3 F 98 ++ Hipp
High NFT 6 AD A3,B3,C3 F 85 ++ Hipp
High NFT 7 AD A3,B3,C3 F 81 ++ Hipp
High NFT 8 AD A3,B3,C3 F 92 ++ Hipp
High NFT 9 AD A3,B3,C3 F 90 ++ Hipp
High NFT 10 AD A3,B3,C3 F 71 ++ Hipp
High NFT 11 AD A3,B3,C3 M 74 ++ Hipp + BG
High NFT 12 AD A3,B3,C3 F 88 ++ Hipp
High NFT 13 AD A3,B3,C3 M 79 ++ Hipp + BG
High NFT 14 AD A3,B3,C3 F 83 ++ Hipp
High NFT 15 AD (early onset) A3,B3,C3 M 69 ++ Hipp
High NFT 16 AD (early onset) A3,B3,C3 M 63 ++ Hipp
High NFT 17 AD (early onset) A3,B3,C3 M 63 ++ Hipp
High NFT 18 AD (early onset) A3,B3,C3 F 60 ++ Hipp
High NFT 19 AD (early onset) A3,B3,C3 M 62 ++ Hipp
High NFT 20 AD (early onset) A3,B3,C3 F 55 ++ Hipp
High NFT 21 AD A2,B2,C2 M 84 ++ Hipp
Moderate NFT 1 AD A2,B3,C2 M 94 + Hipp
Moderate NFT 2 AD A3,B3,C3 F 76 + Hipp
Moderate NFT 3 AD A3,B3,C3 M 69 + Hipp
Moderate NFT 4 AD A3,B3,C3 M 75 + Hipp
Moderate NFT 5 AD A3,B3,C3 F 89 + Hipp
Moderate NFT 6 MCI A1,B2,C1 F 97 + Hipp
Moderate NFT 7 MCI A1,B2,C1 F 85 + Hipp
Moderate NFT 8 MCI A2,B2,C2 M 84 + Hipp
Moderate NFT 9 AD A2,B2,C2 F 84 + Hipp
Moderate NFT 10 MCI A1,B1,C0 F 84 + Hipp
Moderate NFT 11 MCI A1,B1,C1 M 79 + Hipp
Moderate NFT 12 MCI A1,B1,C1 M 90 + Hipp
Moderate NFT 13 MCI A1,B1,C1 M 74 + Hipp
Moderate NFT 14 MCI A1,B1,C0 M 95 + Hipp
Moderate NFT 15 Normal A1,B1,C0 M 77 + Hipp
Moderate NFT 16 MCI A0,B1,C0 M 88 + Hipp
Moderate NFT 17 Vascular Dementia A1,B1,C0 F 89 + Hipp
Moderate NFT 18 Normal A1,B1,C0 M 69 + Hipp
Moderate NFT 19 Normal A0,B1,C0 F 56 + Hipp
Moderate NFT 20 Normal A0,B1,C0 F 59 + Hipp
Moderate NFT 21 Normal A0,B1,C0 M 59 + Hipp
Moderate NFT 22 Normal A1,B1,C0 F 71 + Hipp
Low/no NFT 1 Normal A0,B0,C0 M 77 Hipp
Low/no NFT 2 Normal A0,B0,C0 F 49 Hipp
Low/no NFT 3 Normal A1,B1,C0 M 63 Hipp
Low/no NFT 4 Normal A0,B0,C0 F 51 Hipp
Low/no NFT 5 Normal A0,B0,C0 M 55 Hipp
Low/no NFT 6 Normal A0,B0,C0 M 57 Hipp
Low/no NFT 7 Normal A0,B0,C0 M 59 Hipp
Low/no NFT 8 Normal A0,B0,C0 M 57 Hipp
Low/no NFT 9 Normal A0,B0,C0 M 55 Hipp
Low/no NFT 10 Normal A0,B0,C0 M 54 Hipp
Low/no NFT 11 Normal A0,B0,C0 M 50 Hipp
Low/no NFT 12 Normal A1,B0,C0 M 59 Hipp
Low/no NFT 13 Normal A1,B1,C1 M 89 Hipp
Low/no NFT 14 MCI A2,B1,C1 F 89 Hipp
Low/no NFT 15 MCI A2,B1,C1 M 66 Hipp
Down Syndrome 1 DS, AD A3,B3,C3 F 58 +++ Hipp
Down Syndrome 2 DS, AD A3,B3,C3 F 59 +++ Hipp
Down Syndrome 3 DS, AD A3,B3,C3 M 54 +++ Hipp
Down Syndrome 4 DS, AD A3,B3,C3 M 55 +++ Hipp
Down Syndrome 5 DS, AD A3,B3,C3 F 54 +++ Hipp
PART 1 PART A0,B2,C0 M 75 + Hipp
PART 2 PART A0,B2,C0 F 86 ++ Hipp
PART 3 PART A0,B2,C0 F 92 + Hipp
PART 4 PART A0,B2,C0 M 94 + Hipp
PART 5 PART A0,B2,C0 F 90 ++ Hipp
PART6 PART A0,B2,C0 M 92 ++ Hipp
CBD 1 CBD n/a F 73 +++ BG
CBD 2 CBD n/a M 75 +++ BG
CBD 3 CBD n/a M 79 ++ BG
CBD 4 CBD n/a F 80 + BG
CBD 5 CBD n/a M 68 + BG
PSP 1 PSP n/a M 74 + BG
PSP 2 PSP n/a M 71 ++ BG
PSP 3 PSP n/a M 71 + BG
PSP 4 PSP n/a M 71 + BG
PSP 5 PSP n/a F 87 + BG
PiD 1 Pick’s Disease n/a M 67 + Hipp
PiD 2 Pick’s Disease n/a M 67 ++ Hipp
PiD 3 Pick’s Disease n/a F 71 +++ Hipp
PiD 4 Picks Disease n/a F 65 +++ Hipp
HCHWA-D Dutch amyloidosis n/a F 54 n/a TCx
FTLD-ADRC 1 CBD with AD A0,B1,C0 M 72 n/a Hipp
FTLD-ADRC 2 PSP with AD A1,B3,C0 F 79 n/a Hipp