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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer’s disease and not in other tauopathies

Fig. 6

SCRN1 only colocalizes with AD-associated pathology in a CBD case with AD comorbidity. a-c Astrocytic plaques (asterix) consistent with CBD pathology contained PHF1 positive pTau, but not SCRN1 (a). RD4 (b) and RD3 (c) immunostaining confirmed 4R tau specificity. d-f RD4 positive pre-tangles (e) associated with CBD pathology showed immunoreactivity for PHF1 (d) but not SCRN1. g-i Presence of SCRN1 in lesions containing PHF1(g), RD4 (h) and RD3(i) positive pTau consistent with AD-associated NFTs pathology and dystrophic neurites (arrows). Scale bar for inserts: 25 μm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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