Fig. 4

Secernin-1 accumulates in pTau aggregates in AD, DS and PART but not in PiD, CBD and PSP. a SCRN1 colocalization with PHF1 in AD, DS and AD, PART, Pick’s disease, CBD and PSP. Representative images show SCRN1 staining in the hippocampus in AD, DS and AD, PART and Pick’s disease and of SCRN1 staining in the basal ganglia in CBD and PSP. SCRN1 (green) accumulated in neurofibrillary tangles and in dystrophic neurites in AD, Down syndrome and PART but not in PHF1 positive aggregates (red) in PiD, CBD or PSP. b-e SCRN1 levels were significantly higher in PHF1 positive NFTs and dystrophic neurites than in surrounding neurons in both DS (b) and PART (c), similar to AD. There was limited/no co-localization of SCRN1 with pTau positive neuropathological lesions in Pick’s disease (d), Corticobasal Degeneration and Progressive Supranuclear Palsy (e). *** p-value < 0.001, ** p-value < 0.01, * p-value < 0.05; two-tailed paired t-test