Table 1 Subject characteristics. We observe the expected decrease in brain weight in AD (2-way ANOVA effect of disease F(1,29) = 9.018, P = 0.0055, no significant effect of genotype). The control APOE3/4 group is not age matched. Age is significantly different in AD vs control (2-way ANOVA effect of disease F (1, 29) = 17.4, P = 0.0003, * Tukey’s multiple comparison test control APOE3/4 significantly different from AD APOE3/4 age p = 0.002). There are no differences in age between AD APOE3/4 and AD APOE4/4 cases. There are no significant differences of disease or genotype in post mortem interval (PMI) or brain pH.
MRC BBN number | Clinical diagnosis | ApoE genotype | Sex (f,m) | Age, y | PMI, h | brain weight, g | brain pH | Braak Stage | neuropath diagnosis and co-morbidities |
|---|---|---|---|---|---|---|---|---|---|
BBN_14395 | ctrl | 3/3 | f | 74 | 41 | 1520 | 6.3 | 0 | control, Mild degree of small vessel disease |
BBN_20122 | ctrl | 3/3 | m | 59 | 74 | 1500 | 6.1 | 0 | control, No significant abnormalities |
BBN_22612 | ctrl | 3/3 | m | 61 | 70 | 1300 | 6.1 | 0 | control, No significant abnormalities |
BBN_ 24340 | ctrl | 3/3 | m | 53 | 53 | 1400 | 6.5 | 0 | control, Significant atherosclerosis in larger vessels, mild small vessel disease |
BBN001.26495 | ctrl | 3/3 | m | 78 | 39 | 1290 | 6.17 | I | control, mild Alzheimer’s Disease pathology |
BBN001.28402 | ctrl | 3/3 | m | 79 | 49 | 1503 | 6.33 | I | control, mild Alzheimer's pathology, mild WM pathology, Moderate non-amyloid SVD, Encephalopathy, hepatic |
BBN001.28406 | ctrl | 3/3 | m | 79 | 72 | 1437 | 6.13 | II | control, mild Alzheimer's pathollgy. Moderate arteriolar CAA , WM pathology, Mild non-amyloid SVD |
BBN001.28793 | ctrl | 3/3 | f | 79 | 72 | 1219 | 5.95 | II | control, mild Alzheimer's pathology, moderate WM pathology, moderate non-amyloid SVD |
group medians (IQR) | n = 8 | 2,6 | 76 (18.5) | 61.5 (25) | 1418 (203) | 6.15 (0.2) | |||
BBN_15258 | AD | 3/3 | m | 65 | 80 | 1335 | 6.1 | VI | Alzheimer's Disease, LBD neocrotical subtype |
BBN_19595 | AD | 3/3 | m | 87 | 58 | 1420 | 6.5 | VI | Alzheimer's Disease, CAA, SVD with lacunar infarcts |
BBN_19994 | AD | 3/3 | f | 87 | 89 | 1270 | 5.9 | VI | Alzheimer's Disease, sCAA, Vascular disease lacunar, thrombus, embolus |
BBN_22223 | AD | 3/3 | f | 87 | 83 | 1200 | 6.7 | IV | Alzheimer's Disease, cerebral haemorrhage, vascular disease lacunarBBN_ |
BBN_24527 | AD | 3/3 | m | 81 | 74 | 1160 | 6.1 | VI | Alzheimer's Disease, Vascular Disease lacunar |
BBN001.28410 | AD | 3/3 | f | 62 | 109 | 1029 | 6.04 | VI | Alzheimer's Disease, Mild arteriolar CAA,Moderate non-amyloid SVD |
BBN001.28771 | AD | 3/3 | m | 85 | 91 | 1183 | 5.95 | VI | Alzheimer's disease, Severe arteriolar CAA , WM pathology moderate, Moderate non-amyloid SVD |
BBN_28785 | AD | 3/3 | f | 78 | 76 | 960 | 5.9 | Corticobasal degeneration FTLD, WM pathology, mild. Moderate non-amyloid SVD | |
group medians (IQR) | n = 8 | 4,4 | 83 (12.25) | 81.5 (14) | 1191.5 (159) | 6.07 (0.27) | |||
BBN_15221 | ctrl | 3/4 | m | 53 | 114 | 1650 | 6.1 | 0 | control, No significant abnormalities |
BBN_15809 | ctrl | 3/4 | m | 58 | 90 | 1470 | 5.9 | 0 | control, mild small vessel disease |
BBN_16425 | ctrl | 3/4 | m | 61 | 99 | 1270 | 6.2 | 0 | control, evidence of cerebrovascular disease, no infarcts |
BBN_20593 | ctrl | 3/4 | m | 60 | 52 | 1460 | 6 | 0 | control, no significant abnormalities |
BBN_20120 | ctrl | 3/4 | m | 53 | 97 | 1400 | 6.4 | 0 | control, no significant abnormalities |
BBN_22629 | ctrl | 3/4 | f | 59 | 53 | 1280 | 6.3 | 0 | control, no significant abnormalities |
BBN_2555 | ctrl | 3/4 | m | 74 | 66 | 1350 | 6.3 | 0 | control, small vessel lipohyalinosis, large vessel athersclerosis |
group medians (IQR) | n = 7 | 1,6 | 59 (5)* | 90 (38.5) | 1400 (150) | 6.2 (0.25) | |||
BBN_10591 | AD | 3/4 | m | 86 | 76 | 1470 | VI | Alzheimer's Disease, small vessel disease | |
BBN_15810 | AD | 3/4 | f | 73 | 96 | 1090 | 6.2 | VI | Alzheimer's Disease, vascular disease |
BBN_15811 | AD | 3/4 | f | 81 | 41 | 1457 | 6.3 | VI | Alzheimer's Disease, sCAA, Intracerebral haemorrhage, vascular disease |
BBN_19690 | AD | 3/4 | m | 57 | 58 | 1200 | 5.9 | VI | Alzheimer's disease, |
BBN_23394 | AD | 3/4 | f | 88 | 59 | 1165 | 6.3 | VI | Alzheimer's Disease, sCAA, Intracerebral haemorrhage, vascular disease lacunar |
BBN_24322 | AD | 3/4 | m | 80 | 101 | 1410 | 6 | VI | Alzheimer’s Disease, sCAA |
BBN_24526 | AD | 3/4 | m | 79 | 65 | 1300 | 6.05 | VI | Alzheimer’s Disease |
BBN_25739 | AD | 3/4 | f | 85 | 45 | 1375 | 5.77 | VI | Alzheimer’s Disease, sCAA, focal TDP43 within the entorhinal cortex. |
BBN001.26718 | AD | 3/4 | m | 78 | 74 | 1367 | 6.13 | VI | Alzheimer's disease, moderate non amyloid arteriolar CAA |
BBN_26732 | AD | 3/4 | m | 76 | 66 | 1467 | 6.48 | VI | Alzheimer's disease, Moderate non amyloid arteriolar SVD, Severe arteriorlar CAA, Limbic Lewy body disease |
group medians (IQR) | n = 10 | 4,6 | 79.5 (7.5) | 65.5 (17.3) | 1371 (220.3) | 6 (0.3) |