Table 1 Characteristics of post-mortem human brain samples
Brain Region: Hippocampus (paraffin-embedded) | ||||||
Braak Stage | Number of Subjects | Age at Deatha | Genderb | APOE4 Statusc | CERAD Scored | Diagnosise |
I | 6 | 79 ± 6.8 | M (1) F (5) | + (1), − (2) | O(2), A(2), B(2) | NDCNTRL |
II | 6 | 85.7 ± 1.8 | M (1) F (5) | + (2), − (4) | A(1), B(3), C(2) | NDCNTRL |
III | 6 | 82 ± 5.8 | M (5) F (1) | + (3), − (2) | A(1), B(2), C(3) | NDCNTRL |
IV | 7 | 92.3 ± 3.3 | M (1) F (6) | + (2), − (5) | C | NDCNTRL (2), AD(5) |
V | 4 | 82.3 ± 10.1 | M (0) F (4) | + (3), − (1) | C | AD |
VI | 6 | 86 ± 6.8 | M (0) F (6) | + (4), − (2) | C | AD |
Brain Region: Cortex (paraffin-embedded) | ||||||
Braak Stage | Number of Subjects | Age at Death | Gender | APOE4 Status | CERAD Score | Diagnosis |
I | 4 | 82.5 ± 9.3 | M (2) F (2) | + (0), − (4) | A(1), B(2), C(1) | NDCNTRL |
II | 3 | 85.3 ± 0.5 | M (1) F (2) | + (1), − (2) | A(1), B(3), C(2) | NDCNTRL |
III | 4 | 87 ± 3.7 | M (3) F (1) | + (2), − (2) | A(1), B(2), C(3) | NDCNTRL |
IV | 6 | 89.3 ± 5.4 | M (2) F (4) | + (3), − (3) | B(2), C(4) | NDCNTRL (2), AD (4) |
V | 3 | 84.3 ± 13.2 | M (0) F (3) | + (2), − (1) | C | AD |
VI | 5 | 89.2 ± 3.4 | M (0) F (5) | + (4), − (1) | C | AD |
Brain Region: Cortex (frozen) | ||||||
Braak Stage | Number of Subjects | Age at Death | Gender | APOE4 Status | CERAD Score | Diagnosis |
I – II | 4 | 88.7 ± 7.9 | M (0) F (4) | + (0), − (2) | O(1), A(1), B(1), C(1) | NDCNTRL |
III – IV | 5 | 91.4 ± 2.9 | M (1) F (4) | + (1), − (2) | O(1), B(2), C(2) | NDCNTRL (3), AD (2) |
V – VI | 5 | 75.2 ± 8.1 | M (2) F (3) | + (2), −(2) | B(1), C(4) | AD |