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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson’s disease and multiple system atrophy

Fig. 5

Fluorescence lifetime imaging of h-FTAA- and pS129 α-syn antibody-positive inclusions in multiple system atrophy (MSA) and Parkinson’s disease (PD). a Structure of the luminescent conjugated oligothiophene h-FTAA. b Fluorescence intensity (top) and fluorescence lifetime (bottom) images of h-FTAA stained pS129 positive α-syn inclusions in MSA (case 6, cerebellum) and PD (case 13, substantia nigra) brains. The colour bar represents lifetimes from 200 ps (orange)-900 ps (blue) and the images are colour coded according to lifetime. c Fluorescence lifetime distributions of h-FTAA bound to pS129 positive α-syn deposits in MSA (coral line) and PD (cyan line); 17–44 inclusions from 3 cases of MSA (6, 7 and 8, cerebellum) and 3 cases of PD (13, 15 and 16, substantia nigra) were used. Scale bar, 20 μm

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