Fig. 4

Boxplot diagrams representing the distribution of Aβ phase, AβMTL phase, A-score, CAA stage, CAA severity (a) and Aβ loads (b) in relation to the PET-Aβ phase estimate in cohort 3. All parameters correlated with the PET-Aβ phase estimates (r = 0.610–0.835; p < 0.001; for detailed statistical analysis see Additional file 1: Table S6). Note that the main increase in Aβ load occurs after Aβ became detectable in PET-Aβ phase estimate 1. The mean value of the Aβ load in PET-Aβ phase estimate 1 was 1.396% (median 1.42%) indicative for the threshold of Aβ detectability in the brain by PET