Fig. 3
Boxplot diagram comparing the relationship of the Aβ phases (a), AβMTL phases (b), A-scores (c), CAA stages (d) and CAA severities (e) with the biochemical stages of Aβ aggregate maturation reflecting the hierarchical occurrence of Aβ, AβN3pE, and AβpSer8 in Aβ aggregates in brain homogenates (B-Aβ stages) or in Aβ plaques (B-Aβ plaque stage) in cohort 1. a: The B-Aβ stages and the B-Aβ plaque stages increased with increasing Aβ phase until Aβ phase 4 when the maximum B-Aβ and B-Aβ plaques stages were reached. b, c: AβMTL phases and A-scores also correlated with the B-Aβ stages and B-Aβ plaque stages but exhibiting no ceiling effect. d, e: In the presence of CAA regardless of the stage (d) or severity (e), end-stage B-Aβ stage and B-Aβ plaque stage were observed, probably indicative for a ceiling effect. (Spearman correlation analysis: r = 0.694–0.906) (for detailed statistical analysis see Additional file 1: Table S5a)