Fig. 7

Rare tau pathology in the midbrain is mostly AD-type tau. To further examine whether tau pathology in the midbrain could contribute to neuron loss, midbrain sections from the AD control, PSP control, or LB-negative LRRK2 mutation carriers were labeled with AT8 (green) for total tau pathology and GT-38 (magenta) for AD tau pathology. The AD case had tau pathology in the nigra, most of which was positive for both AT8 and GT-38 (filled arrowheads). The PSP midbrain contained abundant AT8-positive inclusions that were not recognized by GT-38 (empty arrowheads). Almost all tau inclusions in the LRRK2 mutation carriers examined were also GT-38 positive, with the exception of one inclusion identified in p.G2019S-4, which was GT-38 negative. Scale bar = 100 μm