Fig. 3

GT-38 selectively detects AD tau, but not PSP, Pick’s or CBD pathological tau. a AT8 was used to stain pathological tau in 7 regions from 4 different tauopathy brains, PSP, Pick’s disease, CBD and Alzheimer’s disease AD. Consistent with their neuropathological designation as tauopathies, all four diseases had prominent AT8 staining. b GT-38 was used to stain adjacent sections to those stained in panel (a). GT-38 staining is absent in the PSP, Pick’s and CBD tissue, despite the high degree of pathogenic tau. In contrast, GT-38 shows prominent staining in all regions of the AD brain. Scale bar = 100 μm