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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain

Fig. 8

Localization of LGMN is similar in AD and control temporal cortex. Immunohistochemistry analysis of middle temporal gyrus sections from Alzheimer disease (a,c,e,g) and non-demented control (b, d, f, h) subjects. Adjacent sections were used, and images represent matched fields of view. β-amyloid plaques (double arrowhead) were detected in AD (a), but not control (b). Abundant AT100 immunoreactive neuritic plaques (arrow head), neurofibrillary tangles (arrows) and neuropil threads (open arrow) were detected in AD (c). Sparse neurofibrillary tangles and neuropil threads were also detected in controls (d). LGMN immunoreactivity and subcellular distribution was comparable in AD (e, g) and control samples (f, h). LGMN (red) and colocalizes with LAMP2 (green) in both AD and controls (g, h). Scale bars: a-d, 100 μm; e-f, 20 μm; g-h, 10 μm

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