TY - JOUR AU - Schlegel, Kerstin AU - Awwad, Khader AU - Heym, Roland G. AU - Holzinger, David AU - Doell, Annika AU - Barghorn, Stefan AU - Jahn, Thomas R. AU - Klein, Corinna AU - Mordashova, Yulia AU - Schulz, Michael AU - Gasparini, Laura PY - 2019 DA - 2019/11/13 TI - N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain JO - Acta Neuropathologica Communications SP - 177 VL - 7 IS - 1 AB - Intraneuronal insoluble inclusions made of Tau protein are neuropathological hallmarks of Alzheimer Disease (AD). Cleavage of Tau by legumain (LGMN) has been proposed to be crucial for aggregation of Tau into fibrils. However, it remains unclear if LGMN-cleaved Tau fragments accumulate in AD Tau inclusions. SN - 2051-5960 UR - https://doi.org/10.1186/s40478-019-0831-2 DO - 10.1186/s40478-019-0831-2 ID - Schlegel2019 ER -