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Table 2 Top 12 highly secreted cytokines/chemokines/growth factors in the human PitNETs-derived cell culture supernatants (n = 24)

From: Chemokines modulate the tumour microenvironment in pituitary neuroendocrine tumours

Cytokine/ Chemokine/ Growth factorMean concentration (pg/mL) ± SEMSerum-free medium (pg/mL)n (%) of PitNETs with detectable cytokine
IL-8854.18 ± 445.797.0622 (91.7%)
CCL2578.03 ± 222.664.0021 (87.5%)
CCL3150.55 ± 88.22022 (91.7%)
CCL494.25 ± 47.203.0918 (75.0%)
CXCL1076.67 ± 47.58014 (58.3%)
CCL2267.25 ± 16.7420.7815 (62.5%)
CXCL160.30 ± 26.1420.7812 (50.0%)
CX3CL135.14 ± 17.126.7319 (79.2%)
FGF-226.65 ± 4.11019 (79.2%)
IL-624.90 ± 19.27012 (50.0%)
PDGF-AA22.36 ± 6.780.1220 (83.3%)
VEGF-A15.85 ± 4.06018 (75.0%)
  1. PitNETs-derived supernatants collected at 24 h on serum-free medium conditions and cytokine secretome determined with the human Millipore MILLIPLEX cytokine 42-plex array. Data are shown as mean concentration (pg/mL) ± standard error of the mean (SEM). Right column shows the number and percentage of PitNETs with detectable cytokine levels, i.e. cytokine concentration above the lowest standard curve point and serum-free medium quantification