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Table 2 Top 12 highly secreted cytokines/chemokines/growth factors in the human PitNETs-derived cell culture supernatants (n = 24)

From: Chemokines modulate the tumour microenvironment in pituitary neuroendocrine tumours

Cytokine/ Chemokine/ Growth factor

Mean concentration (pg/mL) ± SEM

Serum-free medium (pg/mL)

n (%) of PitNETs with detectable cytokine

IL-8

854.18 ± 445.79

7.06

22 (91.7%)

CCL2

578.03 ± 222.66

4.00

21 (87.5%)

CCL3

150.55 ± 88.22

0

22 (91.7%)

CCL4

94.25 ± 47.20

3.09

18 (75.0%)

CXCL10

76.67 ± 47.58

0

14 (58.3%)

CCL22

67.25 ± 16.74

20.78

15 (62.5%)

CXCL1

60.30 ± 26.14

20.78

12 (50.0%)

CX3CL1

35.14 ± 17.12

6.73

19 (79.2%)

FGF-2

26.65 ± 4.11

0

19 (79.2%)

IL-6

24.90 ± 19.27

0

12 (50.0%)

PDGF-AA

22.36 ± 6.78

0.12

20 (83.3%)

VEGF-A

15.85 ± 4.06

0

18 (75.0%)

  1. PitNETs-derived supernatants collected at 24 h on serum-free medium conditions and cytokine secretome determined with the human Millipore MILLIPLEX cytokine 42-plex array. Data are shown as mean concentration (pg/mL) ± standard error of the mean (SEM). Right column shows the number and percentage of PitNETs with detectable cytokine levels, i.e. cytokine concentration above the lowest standard curve point and serum-free medium quantification