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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Chemokines modulate the tumour microenvironment in pituitary neuroendocrine tumours

Fig. 9

The tumor microenvironment of PitNETs. Pituitary tumour cells release different cytokines, particularly chemokines (including IL-8, CCL2, CCL3, CCL4, CXCL10, CXCL1), directly into the tumour microenvironment promoting the recruitment and infiltration of immune cells, including macrophages, lymphocytes and neutrophils. PitNET-infiltrating immune cells change the behaviour of pituitary tumour cells, namely increasing their proliferative capacity. PitNET-associated fibroblasts are also able to secrete cytokines into the TME, including IL-6 and other chemokines, which in turn lead to increased invasion of pituitary tumour cells

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