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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Chemokines modulate the tumour microenvironment in pituitary neuroendocrine tumours

Fig. 2

Immunohistochemical analysis of immune cells in PitNETs and normal pituitary (NP). Immune cells analysed: macrophages (CD68+), cytotoxic T lymphocytes (CD8+), T helper lymphocytes (CD4+), T regulatory cells (FOXP3+), B cells (CD20+) and neutrophils (neutrophil elastase+). Data are shown as mean ± standard error of the mean for percentage of immune cells compared to the total number of tumour cells, and for CD8:CD4 or CD8:FOXP3 cell ratios. Representative images are shown for NF-PitNET, somatotropinoma and NP. Scale bar 50 μm. PitNETs, n = 24; NPs, n = 5. *,< 0.05, **,< 0.01, ***,< 0.001 (two-way ANOVA with Bonferroni multiple comparison test for immunopositive cell comparative analysis; Mann Whitney U test for cell ratio comparative analysis)

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