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Table 4 Comparison of levels of inflammation-related proteins measured by V-PLEX Meso Scale Discovery Multiplex Assays

From: Microglial motility in Alzheimer’s disease and after Aβ42 immunotherapy: a human post-mortem study

pg/μg total protein

Control

AD

iAD

P value1

P value2

IFNγ

0.125 (0.085-0.206)

0.286 (0.147-0.377)

0.139 (0.052-0.313)

<0.001 (2.3)

0.167

IL1β

0.195 (0.097-0.274)

0.125 (0.085-0.257)

0.208 (0.167-0.427)

0.175

0.175

IL10

0.024 (0.016-0.040)

0.047 (0.033-0.055)

0.038 (0.026-0.050)

0.003 (1.9)

0.301

IL12p70

0.204 (0.156-0.255)

0.367 (0.280-0.478)

0.364 (0.317-0.424)

<0.001 (1.8)

0.986

IL13

0.566 (0.424-0.742)

0.985 (0.786-1.145)

1.718 (1.199-1.870)*

<0.001 (1.7)

0.017 (1.7)

IL2

0.084 (0.067-0.120)

0.141 (0.113-0.180)

0.173 (0.143-0.222)

0.002 (1.7)

0.172

IL4

0.023 (0.017-0.033)

0.045 (0.038-0.056)

0.042 (0.035-0.051)

0.007 (1.9)

0.779

IL6

0.644 (0.192-1.015)

0.347 (0.209-0.573)

0.585 (0.187-1.445)

0.482

0.482

IL8

2.694 (1.428-6.597)

1.530 (1.221-3.419)

2.796 (2.300-5.561)

0.081

0.023 (1.8)

TNFα

0.112 (0.089-0.141)

0.200 (0.147-0.247)

0.196 (0.152-0.215)

<0.001 (1.8)

0.575

GM-CSF

0.000 (0.000-0.001)

0.000 (0.000-0.002)

0.000 (0.000-0.000)

0.682

0.682

IL1α

0.043 (0.026-0.065)

0.047 (0.029-0.082

0.044 (0.034-0.079)

0.735

0.735

IL12/IL23p40

0.079 (0.054-0.116)

0.064 (0.044-0.100)

0.094 (0.072-0.132)

0.163

0.163

IL15

0.637 (0.493-0.711)

0.744 (0.638-0.929)

1.026 (0.768-1.366)

0.024 (1.2)

0.053

IL16

19.30 (14.33-24.84)

30.19 (20.65-46.03)

35.13 (25.41-46.57)

0.020 (1.6)

0.617

IL17A

0.000 (0.000-0.000)

0.000 (0.000-0.000)

0.000 (0.000-0.000)

0.839

0.839

IL5

0.000 (0.000-0.000)

0.000 (0.000-0.000)

0.000 (0.000-0.000)

0.677

0.677

IL7

0.036 (0.022-0.049)

0.027 (0.013-0.064)

0.003 (0.000-0.015)*

0.323

0.012 (0.1)

TNFβ

0.005 (0.003-0.007)

0.012 (0.004-0.016)

0.005 (0.000-0.013)

0.009 (2.4)

0.143

VEGF

1.630 (0.937-4.511)

1.056 (0.537-2.436)

5.524 (4.292-6.497)*

0.066

<0.001 (5.2)

  1. Values are median with IQR, P value by Kruskal-Wallis test with Dunn’s test as post hoc pairwise comparison;
  2. Significant P value in italic with the fold change between brackets
  3. 1AD vs. control, 2iAD vs. AD
  4. Control neurologically/cognitively normal controls, AD Alzheimer’s disease cases, iAD immunised Alzheimer’s disease cases
  5. * These values are significantly different from both AD and the control group (IL13: P<0.001 (3.03); IL7: P=0.003 (0.08); VEGF: P=0.012 (-3.39)
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Acta Neuropathologica Communications

ISSN: 2051-5960

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