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Table 4 Comparison of levels of inflammation-related proteins measured by V-PLEX Meso Scale Discovery Multiplex Assays

From: Microglial motility in Alzheimer’s disease and after Aβ42 immunotherapy: a human post-mortem study

pg/μg total proteinControlADiADP value1P value2
IFNγ0.125 (0.085-0.206)0.286 (0.147-0.377)0.139 (0.052-0.313)<0.001 (2.3)0.167
IL1β0.195 (0.097-0.274)0.125 (0.085-0.257)0.208 (0.167-0.427)0.1750.175
IL100.024 (0.016-0.040)0.047 (0.033-0.055)0.038 (0.026-0.050)0.003 (1.9)0.301
IL12p700.204 (0.156-0.255)0.367 (0.280-0.478)0.364 (0.317-0.424)<0.001 (1.8)0.986
IL130.566 (0.424-0.742)0.985 (0.786-1.145)1.718 (1.199-1.870)*<0.001 (1.7)0.017 (1.7)
IL20.084 (0.067-0.120)0.141 (0.113-0.180)0.173 (0.143-0.222)0.002 (1.7)0.172
IL40.023 (0.017-0.033)0.045 (0.038-0.056)0.042 (0.035-0.051)0.007 (1.9)0.779
IL60.644 (0.192-1.015)0.347 (0.209-0.573)0.585 (0.187-1.445)0.4820.482
IL82.694 (1.428-6.597)1.530 (1.221-3.419)2.796 (2.300-5.561)0.0810.023 (1.8)
TNFα0.112 (0.089-0.141)0.200 (0.147-0.247)0.196 (0.152-0.215)<0.001 (1.8)0.575
GM-CSF0.000 (0.000-0.001)0.000 (0.000-0.002)0.000 (0.000-0.000)0.6820.682
IL1α0.043 (0.026-0.065)0.047 (0.029-0.0820.044 (0.034-0.079)0.7350.735
IL12/IL23p400.079 (0.054-0.116)0.064 (0.044-0.100)0.094 (0.072-0.132)0.1630.163
IL150.637 (0.493-0.711)0.744 (0.638-0.929)1.026 (0.768-1.366)0.024 (1.2)0.053
IL1619.30 (14.33-24.84)30.19 (20.65-46.03)35.13 (25.41-46.57)0.020 (1.6)0.617
IL17A0.000 (0.000-0.000)0.000 (0.000-0.000)0.000 (0.000-0.000)0.8390.839
IL50.000 (0.000-0.000)0.000 (0.000-0.000)0.000 (0.000-0.000)0.6770.677
IL70.036 (0.022-0.049)0.027 (0.013-0.064)0.003 (0.000-0.015)*0.3230.012 (0.1)
TNFβ0.005 (0.003-0.007)0.012 (0.004-0.016)0.005 (0.000-0.013)0.009 (2.4)0.143
VEGF1.630 (0.937-4.511)1.056 (0.537-2.436)5.524 (4.292-6.497)*0.066<0.001 (5.2)
  1. Values are median with IQR, P value by Kruskal-Wallis test with Dunn’s test as post hoc pairwise comparison;
  2. Significant P value in italic with the fold change between brackets
  3. 1AD vs. control, 2iAD vs. AD
  4. Control neurologically/cognitively normal controls, AD Alzheimer’s disease cases, iAD immunised Alzheimer’s disease cases
  5. * These values are significantly different from both AD and the control group (IL13: P<0.001 (3.03); IL7: P=0.003 (0.08); VEGF: P=0.012 (-3.39)