Microglial motility in Alzheimer’s disease and after Aβ42 immunotherapy: a human post-mortem study

Table 2 Correlation of motility-related markers with pan-Aβ, Aβ42 and ptau

		Iba1	CFL1	P2RY12	CORO1A
pan-Aβ	Control	r_s = 0.440*	r_s = 0.301	r_s = 0.443*	r_s = 0.055
	AD	r_s = −0.055	r_s = 0.077	r_s = 0.219	r_s = 0.009
	iAD	r_s = −0.143	r_s = 0.011	r_s = 0.054	r_s = −0.029
Aβ42	Control	r_s = 0.691***	r_s = 0.459	r_s = 0.629***	r_s = 0.051
	AD	r_s = −0.021	r_s = − 0.172	r_s = 0.078	r_s = − 0.158
	iAD	r_s = −0.464	r_s = −0.575	r_s = 0.171	r_s = 0.464
ptau	Control	rs = −0.113	rs = −0.165	rs = 0.017	rs = 0.-173
	AD	rs = −0.239	rs = −0.043	rs = − 0.249	rs = − 0.019
	iAD	rs = −0.709	rs = − 0.118	rs = 0.191	rs = 0.036

r_s Spearman’s rank correlation, *P < 0.05; *** P < 0.001, significant P values are in italic
CFL1 cofilin 1, CORO1A coronin-1A
Control neurologically/cognitively normal controls, AD Alzheimer’s disease cases, iAD immunised Alzheimer’s disease cases, ptau: phosphorylated tau

ISSN: 2051-5960