TY - JOUR AU - Franco-Bocanegra, Diana K. AU - George, Bethany AU - Lau, Laurie C. AU - Holmes, Clive AU - Nicoll, James A. R. AU - Boche, Delphine PY - 2019 DA - 2019/11/08 TI - Microglial motility in Alzheimer’s disease and after Aβ42 immunotherapy: a human post-mortem study JO - Acta Neuropathologica Communications SP - 174 VL - 7 IS - 1 AB - Microglial function is highly dependent on cell motility, with baseline motility required for homeostatic surveillance activity and directed motility to migrate towards a source of injury. Experimental evidence suggests impaired microglial motility in Alzheimer’s disease (AD) and therefore we have investigated whether the expression of proteins associated with motility is altered in AD and affected by the Aβ immunotherapy using post-mortem brain tissue of 32 controls, 44 AD cases, and 16 AD cases from our unique group of patients immunised against Aβ42 (iAD). SN - 2051-5960 UR - https://doi.org/10.1186/s40478-019-0828-x DO - 10.1186/s40478-019-0828-x ID - Franco-Bocanegra2019 ER -