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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: DNA repair deficiency and senescence in concussed professional athletes involved in contact sports

Fig. 7

Upregulation of pro-inflammatory SASP factors in cases compared to controls. In a heatmap representing gene expression a, cases display high expression (indicated in red) of pro-inflammatory SASP factors compared to various controls which show low expression (indicated in green). Furthermore, representation of log2 RNA count number of various SASP genes (b) shows significant up-regulation of these genes in cases compared to controls. The genes shown here are: CCL1*, CCL11*, CCL13*, CCL16*, CCL2, CCL20*, CCL25*, CCL26*, CCL3*, CCL4***, CCL8***, CXCL1**, CXCL11*, CXCL2, CXCL3, CXCL5*, CXCL6*, CXCL8*, CXCR2*, IL11, IL12A, IL12B*, IL13*, IL15*, IL1A*, IL1B*, IL2*, IL4*, IL6*, IL7*, Il6R, NFATC1***, NFATC2**, and NOX4*. Statistical significance was determined using an unpaired student’s t-test with significance denoted at p ≤ 0.05

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