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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: DNA repair deficiency and senescence in concussed professional athletes involved in contact sports

Fig. 4

Expression of genes involved in the DNA damage response (DDR), shown as log2 fold change in cases compared to controls. Genes which are down-regulated are involved in genomic stability in response to stress (RAD17, HUS1), proteins which are degraded upon DNA damage (MDM2), proteins which respond to UV damage and single-stranded breaks (DDB1, DDB2, ATRIP, ATR), and genes whose inhibition lead to DDR-mediated cell-cycle arrest and repair (RNF8). Genes which are up-regulated are all involved in DDR signalling in response to DNA damage. Statistical significance was determined using a student t-test with significance at p ≤ 0.05

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