Fig. 4
From: DNA repair deficiency and senescence in concussed professional athletes involved in contact sports
Expression of genes involved in the DNA damage response (DDR), shown as log2 fold change in cases compared to controls. Genes which are down-regulated are involved in genomic stability in response to stress (RAD17, HUS1), proteins which are degraded upon DNA damage (MDM2), proteins which respond to UV damage and single-stranded breaks (DDB1, DDB2, ATRIP, ATR), and genes whose inhibition lead to DDR-mediated cell-cycle arrest and repair (RNF8). Genes which are up-regulated are all involved in DDR signalling in response to DNA damage. Statistical significance was determined using a student t-test with significance at p ≤ 0.05