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Table 1 Clinical, histological and genetic characteristics of 134 patients

From: Improved risk-stratification for posterior fossa ependymoma of childhood considering clinical, histological and genetic features – a retrospective analysis of the HIT ependymoma trial cohort

Parameter Number of patients%
 (median; range in years)
Gendermale8261.2
female5238.8
Age at diagnosis (years)<  35742.5
 (1.72; 0.21–2.97) 
>  37757.5
 (5.09; 3.01–15.90) 
Extent of resectionGTR8764.9
STR4735.1
Initially metastatic diseaseyes32.2
no13197.8
5-year EFSno event8059.7
5-year OSalive10679.1
WHO-gradeII2619.4
III10880.6
Mitotic activity (mitoses / 10 HPF)≤ 1067 
 (4; 0–10)50
>  1067 
 (25; 11–169)50
Presence of necrosisyes10477.6
no3022.4
Presence of vascular proliferationyes10276.1
no3223.9
Presence of ependymal rosettesyes107.5
no12492.5
Genomic groupnumerical3727.6
balanced5843.3
structural3929.1
Chromosome 1q gainyes2820.9
no10679.1
Polyploid cytogenetic profile /PFByes64.5
 no12895.5