Table 1 Clinical, histological and genetic characteristics of 134 patients
Parameter | Number of patients | % | |
|---|---|---|---|
(median; range in years) | |||
Gender | male | 82 | 61.2 |
female | 52 | 38.8 | |
Age at diagnosis (years) | < 3 | 57 | 42.5 |
(1.72; 0.21–2.97) | |||
> 3 | 77 | 57.5 | |
(5.09; 3.01–15.90) | |||
Extent of resection | GTR | 87 | 64.9 |
STR | 47 | 35.1 | |
Initially metastatic disease | yes | 3 | 2.2 |
no | 131 | 97.8 | |
5-year EFS | no event | 80 | 59.7 |
5-year OS | alive | 106 | 79.1 |
WHO-grade | II | 26 | 19.4 |
III | 108 | 80.6 | |
Mitotic activity (mitoses / 10 HPF) | ≤ 10 | 67 | |
(4; 0–10) | 50 | ||
> 10 | 67 | ||
(25; 11–169) | 50 | ||
Presence of necrosis | yes | 104 | 77.6 |
no | 30 | 22.4 | |
Presence of vascular proliferation | yes | 102 | 76.1 |
no | 32 | 23.9 | |
Presence of ependymal rosettes | yes | 10 | 7.5 |
no | 124 | 92.5 | |
Genomic group | numerical | 37 | 27.6 |
balanced | 58 | 43.3 | |
structural | 39 | 29.1 | |
Chromosome 1q gain | yes | 28 | 20.9 |
no | 106 | 79.1 | |
Polyploid cytogenetic profile /PFB | yes | 6 | 4.5 |
no | 128 | 95.5 |