Fig. 2

Kaplan Meier plots derived from 139 patients diagnosed with an anaplastic astrocytoma or glioblastoma. a There is an association between overall survival and IDH status and (b) between overall survival and MGMT status. c There is a significant effect in the combination of histopathological diagnosis and IDH status. Patients with anaplastic astrocytoma and IDH mutation show better overall survival than patients with anaplastic astrocytoma without IDH mutation and patients diagnosed with glioblastoma with/without IDH mutation. The overall survival of the patients of the latter three subgroups appears similar in the Kaplan Meier analysis. d The same significant effect regarding histopathological diagnosis and IDH status became evident when only patients were subject to analysis below the age of 65 years. e Combining IDH and MGMT status patients with a positivity for both markers performed better than those patients with a negative IDH status independent from the MGMT status. Because only one tumor showed the combination IDH+ and MGMT- this group was not plotted. f Analyzing the histopathological diagnosis in combination with the MGMT status patients with an anaplastic astrocytoma with MGMT promoter methylation showed a better overall survival than the other groups. However, only 3 patients with an anaplastic astrocytoma revealed a negative MGMT promoter status so no further conclusion could be drawn from this group. AA: anaplastic astrocytoma, GBM: glioblastoma, IDH+: IDH1 or IDH2 mutation, IDH-: no IDH1 or IDH2 mutation, MGMT+: promoter methylation, MGMT-: no promoter methylation