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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Synergistic toxicity in an in vivo model of neurodegeneration through the co-expression of human TDP-43M337V and tauT175D protein

Fig. 4

GFP-tau pathology is increased in the presence of TDP-43M337V expression. a GFP-tau positive hippocampal neuron demonstrating a fibril type inclusion (inset, open arrow). b Photomicrograph of a GFP-tau immunoreactive hippocampal neuron demonstrating a neuronal inclusion (arrow), axonal swelling (asterisk), and axonal beading (arrowheads). Note that the latter is nonspecific as it was observed across all groups. c GFP-tau positive hippocampal neurons showing frequent incidence of pathological inclusions (arrowheads, inset). Scale bars = 20 μm. d Bar graph showing frequency of pathological inclusions in hippocampus at 20x magnification in each group (GFP = GFP only control, tauWT = GFP-tagged tauWT, tauT175D = GFP-tagged tauT175D). White bars indicate wild-type Sprague-Dawley rats injected with rAAV9 GFP-tau constructs, green bars indicate ChAT-tTA/TRE-TDP-43M337V rats expressing human TDP-43M337V injected with rAAV9 GFP-tau constructs (n = 3 animals per group)

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