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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an α-synuclein based rat model for Parkinson’s disease

Fig. 5

Chronic neuronal activation induces changes in synaptic proteins in the striatum. a Representative western blots of the total striatal fraction for the presynaptic proteins (synaptophysin and synaptobrevin), the postsynaptic protein (PSD-95) and loading control vinculin (VCL). b - d Quantifications of the western blot: Synaptophysin relative to loading control vinculin (VCL) (b), Synaptobrevin relative to loading control vinculin (VCL) (c) or PSD-95 relative to loading control vinculin (VCL) (d). In all graphs the results have been normalized to mCherry/α-SYN + CNO control, which has been artificially set to 1 (n = 6, Mean ± SD, Unpaired T-Test, **p < 0.01)

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