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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Increased soluble amyloid-beta causes early aberrant brain network hypersynchronisation in a mature-onset mouse model of amyloidosis

Fig. 7

Evaluation of inflammatory responses in the Tet-Off APP mice. At 8w post DOX treatment, no obvious any sign of microgliosis (Iba1, red) or astrogliosis (GFAP, green) was found in the TG mice and control littermates. At 28w post DOX treatment, the TG mouse showed an accumulation of astrocytes and microglia surrounding the plaques, as compared to an age-matched control mouse (nuclear counterstain TOPRO in blue). Scale bar, 200 μm

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