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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Increased soluble amyloid-beta causes early aberrant brain network hypersynchronisation in a mature-onset mouse model of amyloidosis

Fig. 4

Aberrant FC in the default mode-like network in the Tet-Off APP mice. The brain schematics illustrate the difference in FC within (nodes) and between (lines) regions in the DMN over time (week 0 (a), week 8 (b), week 16 (c) and week 28 (d)), overlaid on a 3D anatomical template surface. The inter-node FC difference is represented by the lines, with the colour scale illustrating the actual FC difference between Tet-Off APP and Ctrl (TG-Ctrl), with orange indicating a stronger connection in the TG mice. The intra-node size represents the difference (TG-Ctrl) of the average FC of a specific region with all other regions inside the default mode-like network. The intra-node FC difference is described by larger or smaller spheres, with pink indicating a larger node FC within the DMN in Tet-Off APP mice compared to age-matched Ctrl mice

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