Fig. 1From: Increased soluble amyloid-beta causes early aberrant brain network hypersynchronisation in a mature-onset mouse model of amyloidosisTet-Off APP mouse model. The Tet-Off APP mice, bearing a chimeric APP (mo/huAPP695) which is co-expressed with the tetracycline-Transactivator (tTA). The APP expression can be turned off (left panel) or on (right panel) in the presence or absence of doxycycline (DOX) respectivelyBack to article page