Table 2 Summary of pathological tau inclusion patterns in selected patients with FTLD-tau/MAPT
Pathological changes in FTLD-tau/MAPT | IVS10 + 16 C- > T | V337 M | A152T | P301L |
|---|---|---|---|---|
Cortical Layer NCI distribution | 2, 5–6 | 2, 5–6 | 5 (PSP) | 2, 5–6 |
Preferential VEN and fork cell tau aggregation | Yes | Yes | Yes | No |
Hyperphosphorylation at serine 202 (CP13) | Yes | Yes | Yes | Yes |
Acetylation at k274 (MAB359) | Moderate | Mild | Mild | Mild |
Tau conformational change in NCIs (MC1) | Mild-moderate | Mild | Absent-Mild | Moderate-Severe |