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Table 1 Subject demographics

From: Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants

Case no. Clinical Dx Primary Neuropathological Dx MAPT variant Age/Sex Symptom duration (yr) PMI (hr) Thal phase Braak stage CERAD score ADNC CDR score
FTLD-tau/MAPT
1 bvFTD/PSP-RS FTLD-tau/MAPT IVS10 + 16 C > T 60/M 8 12.5 ND 1 absent Low 2a
2 bvFTD FTLD-tau/MAPT IVS10 + 16 C > T 60/M 13 15.8 1 0 absent Low 3b
3 bvFTD FTLD-tau/MAPT IVS10 + 16 C > T 63/F 17 19.7 1 0 absent Low 3
4 bvFTD FTLD-tau/MAPT P301L 59/F 4 24.2 1 1 absent Low 2
5 bvFTD FTLD-tau/MAPT P301L 75/M 9 8.6 1 2 absent Low 3
6 bvFTD FTLD-tau/MAPT V337 M 68/F 13 18.0 0 1 absent Not 3
7 PSP-RS PSP A152T 56/F 6 5.7 2 2 absent Low 3
8 nfvPPA CBD A152T 63/M 10 > 48 h 1 3 absent Low 1
Average     63 10 15 1 1    2.5
Sporadic bvFTD-PiD
1 bvFTD PiD None 60/F 6 15.1 2–3 1 moderate Low 3c
2 bvFTD PiD None 57/M 6 21.7 0 0 absent Not 2d
3 bvFTD PiD None 70/M 10 10.2 2 0 moderate Low n/a
4 bvFTD PiD None 72/M 9 24.3 0 0 absent Not 3
5 bvFTD PiD None 69/F 13 6.3 0 2 absent Not 3
6 bvFTD PiD None 76/F 13 25.5 0 0 absent Not 3
7 bvFTD PiD None 57/M 13 12.4 1 1 absent Low 3
Average     66 10 17 1 1    2.8
  1. aantemortem, 3 months prior to death, bantemortem, 20 months prior to death, cantemortem, 18 months prior to death, dantemortem, 7 months prior to death, diagnosis (Dx), behvaioral variant FTD (bvFTD), progressive supranuclear palsy-Richardson syndrome (PSP-RS), nonfluent variant primary progressive aphasia (nfvPPA), corticobasal degeneration (CBD), Pick’s disease (PiD), Postmortem interval (PMI)