Table 1 Depressive-like phenotype in mice. Relative score of PAI-1 knockout mice and tPA knockout mice
Depressive-like behaviors in mice | PAI-1−/− | tPA−/− | |
|---|---|---|---|
Apathetic behavior | Splash test | 1 | 0 |
Anhedonic behavior | Sucrose preference test | 1 | 0 |
Body weight | Balance | 1 | 1 |
Hypoactivity or hyperactivity | Actimetry | 0 | 0 |
Loss of motivation/effort | Rotarod | 1 | 0 |
Deficits of self-centered behaviors | Coat state | 1 | 1 |
Cognitive deficits | T-maze | 1 | 1 |
Composite Score | 6 | 3 | |