Fig. 4
PAI-1 knockout mice fail to respond to escitalopram treatment. Evaluation of the behavioral phenotype of PAI-1 knockout mice submitted to an escitalopram chronic treatment (35 days) at 15 mg/kg. Escitalopram: ESC; Vehicle (NaCl 0.9%): VEH. a Splash test: nVEH = 17; nESC = 18. b Coat state: nVEH = 17; nESC = 18. c Sucrose preference test: nVEH = 17; nESC = 18. d Body weight: nVEH = 17; nESC = 18. e Actimetry: nVEH = 17; nESC = 17. f Rotarod: nVEH = 11; nESC = 12. g Forced swimming test: nVEH = 17; nESC = 17. Mann-Whitney U-tests (a, c, d, g), Student t tests (b, e, f): P > 0.05. Boxplots show distributions with black horizontal lines indicating the median, box margins denoting the lower and upper quartiles. Whiskers show the minimum and maximum values