Fig. 2

Influence of PAI-1 deficiency on depressive-like phenotype is independent of tPA and mBDNF. Fibrin-agar zymography assays (tPA proteolytic activity) and immunoblots (mBDNF levels) in the prefrontal cortex (a, b), hippocampus (c, d), and hypothalamus (e, f) of PAI-1 knockout mice (PAI-1−/−) and of their wild-type littermates (PAI-1+/+). n = 5 for each structure / genotype. Student t tests: P > 0.05. Boxplots show distributions with black horizontal lines indicating the median, box margins denoting the lower and upper quartiles. Whiskers show the minimum and maximum values