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Table 2 Enrichment of molecular function and cellular component GO-terms in BA and CCA ECs. Top 5 GO molecular function and cellular component terms higher expressed in the BA compared to the CCA and vice versa. FDR is false discovery rate.0020

From: Profiling the unique protective properties of intracranial arterial endothelial cells

Gene set enrichment analysis on GO molecular function terms

Top 5 GO-terms higher expressed in basilar artery compared to carotid artery

 G0-term

Molecular function

P-value

FDR

  GO:0003735

STRUCTURAL_CONSTITUENT_OF_RIBOSOME

6.27E-07

3.51E-04

  GO:0003743

TRANSLATION_INITIATION_FACTOR_ACTIVITY

9.51E-06

2.31E-03

  GO:0044822

POLY_A_RNA_BINDING

7.67E-05

9.26E-03

  GO:0016675

OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_HEME_GROUP_OF_DONORS

2.00E-04

1.65E-02

  GO:0045182

TRANSLATION_REGULATOR_ACTIVITY

2.11E-04

1.67E-02

Top 5 GO-terms higher expressed in carotid artery compared to basilar artery

 G0-term

Molecular function

P-value

FDR

  GO:0042605

PEPTIDE_ANTIGEN_BINDING

6.42E-05

8.68E-03

  GO:0008329

SIGNALING_PATTERN_RECOGNITION_RECEPTOR_ACTIVITY

4.08E-04

2.55E-02

  GO:0004896

CYTOKINE_RECEPTOR_ACTIVITY

8.94E-04

3.92E-02

  GO:0001653

PEPTIDE_RECEPTOR_ACTIVITY

1.24E-03

4.74E-02

  GO:0004115

3_5_CYCLIC_AMP_PHOSPHODIESTERASE_ACTIVITY

1.40E-03

5.10E-02

Gene set enrichment analysis on GO cellular component terms

Top 5 GO-terms higher expressed in basilar artery compared to carotid artery

 G0-term

Cellular component

P-value

FDR

  GO:0044391

RIBOSOMAL_SUBUNIT

8.67E-08

1.02E-04

  GO:0022626

CYTOSOLIC_RIBOSOME

9.69E-08

1.02E-04

  GO:0015934

LARGE_RIBOSOMAL_SUBUNIT

1.65E-07

1.39E-04

  GO:0005840

RIBOSOME

2.92E-07

2.02E-04

  GO:0015934

CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT

2.99E-07

2.02E-04

Top 5 GO-terms higher expressed in carotid artery compared to basilar artery

 G0-term

Cellular component

P-value

FDR

  GO:0042611

MHC_PROTEIN_COMPLEX

1.90E-06

7.49E-04

  GO:0042613

MHC_CLASS_II_PROTEIN_COMPLEX

5.47E-05

8.05E-03

  GO:0032281

AMPA_GLUTAMATE_RECEPTOR_COMPLEX

2.00E-04

1.65E-02

  GO:0061702

INFLAMMASOME_COMPLEX

3.85E-04

2.49E-02

  GO:0005858

AXONEMAL_DYNEIN_COMPLEX

4.33E-04

2.63E-02