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Table 2 Enrichment of molecular function and cellular component GO-terms in BA and CCA ECs. Top 5 GO molecular function and cellular component terms higher expressed in the BA compared to the CCA and vice versa. FDR is false discovery rate.0020

From: Profiling the unique protective properties of intracranial arterial endothelial cells

Gene set enrichment analysis on GO molecular function terms
Top 5 GO-terms higher expressed in basilar artery compared to carotid artery
 G0-term Molecular function P-value FDR
  GO:0003735 STRUCTURAL_CONSTITUENT_OF_RIBOSOME 6.27E-07 3.51E-04
  GO:0003743 TRANSLATION_INITIATION_FACTOR_ACTIVITY 9.51E-06 2.31E-03
  GO:0044822 POLY_A_RNA_BINDING 7.67E-05 9.26E-03
  GO:0016675 OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_HEME_GROUP_OF_DONORS 2.00E-04 1.65E-02
  GO:0045182 TRANSLATION_REGULATOR_ACTIVITY 2.11E-04 1.67E-02
Top 5 GO-terms higher expressed in carotid artery compared to basilar artery
 G0-term Molecular function P-value FDR
  GO:0042605 PEPTIDE_ANTIGEN_BINDING 6.42E-05 8.68E-03
  GO:0008329 SIGNALING_PATTERN_RECOGNITION_RECEPTOR_ACTIVITY 4.08E-04 2.55E-02
  GO:0004896 CYTOKINE_RECEPTOR_ACTIVITY 8.94E-04 3.92E-02
  GO:0001653 PEPTIDE_RECEPTOR_ACTIVITY 1.24E-03 4.74E-02
  GO:0004115 3_5_CYCLIC_AMP_PHOSPHODIESTERASE_ACTIVITY 1.40E-03 5.10E-02
Gene set enrichment analysis on GO cellular component terms
Top 5 GO-terms higher expressed in basilar artery compared to carotid artery
 G0-term Cellular component P-value FDR
  GO:0044391 RIBOSOMAL_SUBUNIT 8.67E-08 1.02E-04
  GO:0022626 CYTOSOLIC_RIBOSOME 9.69E-08 1.02E-04
  GO:0015934 LARGE_RIBOSOMAL_SUBUNIT 1.65E-07 1.39E-04
  GO:0005840 RIBOSOME 2.92E-07 2.02E-04
  GO:0015934 CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT 2.99E-07 2.02E-04
Top 5 GO-terms higher expressed in carotid artery compared to basilar artery
 G0-term Cellular component P-value FDR
  GO:0042611 MHC_PROTEIN_COMPLEX 1.90E-06 7.49E-04
  GO:0042613 MHC_CLASS_II_PROTEIN_COMPLEX 5.47E-05 8.05E-03
  GO:0032281 AMPA_GLUTAMATE_RECEPTOR_COMPLEX 2.00E-04 1.65E-02
  GO:0061702 INFLAMMASOME_COMPLEX 3.85E-04 2.49E-02
  GO:0005858 AXONEMAL_DYNEIN_COMPLEX 4.33E-04 2.63E-02